Advanced Licap Technology

Licaps are available in a range of standard capsule sizes from 000 (largest) to 1 (smallest). The liquid fill volume varies from approximately 0.50 mL (Size 1) to 1.23 mL (Size 000), allowing for flexibility in formulation and dosing. The specific size selection depends on the required dose of active ingredients, the nature of the formulation, and the target consumer demographics.

Licap technology enhances bioavailability through several mechanisms:

1. Pre-dissolution: The active ingredients are already dissolved or suspended in a liquid matrix, eliminating the dissolution step required for solid forms.

2. Lipid carriers: Many Licap formulations utilize lipid-based delivery systems that can enhance the absorption of poorly water-soluble compounds.

3. Enhanced permeability: Certain excipients used in Licap formulations can temporarily increase intestinal permeability, facilitating improved absorption.

4. Protection: The hermetic seal protects sensitive ingredients from degradation before they reach their absorption site.

These factors can lead to significantly higher bioavailability compared to traditional solid dosage forms, particularly for lipophilic and poorly water-soluble compounds.

Licap technology is particularly beneficial for:

• Lipophilic (fat-soluble) compounds such as vitamins A, D, E, and K

• Oxygen-sensitive ingredients like fish oils, essential fatty acids, and CoQ10

• Compounds with poor water solubility that benefit from lipid-based delivery

• Ingredients with unpleasant taste or odor that need effective masking

• Volatile compounds that require protection from evaporation

• Ingredients that benefit from enhanced bioavailability

• Combinations of ingredients with different solubility profiles

Licaps differ from softgel capsules in several important ways:

Leak-Proof Design: Licaps use a fusion-sealing technology that makes them more leak-proof and chemically stable than softgels, which are prone to melting or leakage under certain conditions.

Clean-Label Formulation: Licaps typically require no gelatin, plasticizers, or added fillers, while softgels often contain gelatin and additives, making Licaps a cleaner and more natural choice.

Heat Sensitivity: Licaps are better suited for heat-sensitive ingredients, as their manufacturing process uses lower temperatures, unlike softgels, which often involve heat that can degrade sensitive actives like probiotics or enzymes.

Gastric Protection & Targeted Release: Licaps can be designed for targeted or delayed release, helping reduce gastric irritation — a feature not generally available in softgels.

Shelf Life and Stability: Thanks to their tight seal and barrier protection, Licaps offer better shelf life and oxidation resistance compared to softgels.

Less Odor and Taste Leakage: The fusion-locked Licaps minimize unpleasant smell or taste, especially for strong ingredients like fish oil — softgels may still release some odor.

The shelf life of Licap products typically ranges from 24 to 36 months, depending on the specific formulation, active ingredients, and storage conditions. The hermetic seal and oxygen barrier properties of Licaps often contribute to extended stability compared to traditional capsules, particularly for oxidation-sensitive ingredients.

At Med Care Factory, we conduct comprehensive stability studies for all Licap formulations to determine accurate shelf-life data under various storage conditions. We can provide guidance on expected stability and optimal packaging configurations to maximize product shelf life.